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Short answer
Schedule the post in Later, then click Setup Automation in the popup that appears. Set your trigger words, public reply and DM, and publish the automation. When the post goes live, the automation moves onto it straight away, so the first comments are answered.
If you closed the popup, click the post in the calendar. In the Comment Automation box (Story DM Automation for stories), click Go to Automation Setup. If an automation is already attached, the box says Automation attached and has Edit Automation.
Tap Later on Home and schedule an image, carousel or Reel. In the “Post Scheduled!” popup tap Setup Automation, or Maybe Later. To come back to it, tap the scheduled post and use its Comment Automation banner.
Nothing changes for them. When the post goes live and someone comments your trigger word, they get your public reply and DM, as with any automated post.
Open the post in Later, click Edit Automation, and switch off the Send Link or PDF card. After publishing, use How do I turn off, edit or delete an automation?
Yes. The automation is moved to the real post the moment it is published, so early comments are covered.
Not before it's published. Wait until the post is live and pick it as a normal post. A Next post automation can't use a flow either: it only offers Send Link & PDF.
Yes. For a scheduled story, the popup offers a story reply automation, so people who reply to the story get your DM.